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1994-07-02
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Document 0077
DOCN M9470077
TI Cerebrovascular and neurological disorders associated with
antiphospholipid antibodies in CSF and serum.
DT 9409
AU Gallo P; Sivieri S; Ferrarini AM; Giometto B; Ruffatti A; Ritter E;
Chizzolini C; Tavolato B; Institute of Neurology, University of Padua,
School of Medicine,; Italy.
SO J Neurol Sci. 1994 Mar;122(1):97-101. Unique Identifier : AIDSLINE
MED/94253843
AB Paired serum and cerebrospinal fluid (CSF) samples from 70 patients with
inflammatory and non-inflammatory neurological diseases, as well as 10
sera from patients with primary antiphospholipid syndrome (PAS), six of
which presented with cerebrovascular ischemic syndromes, were studied
for the presence of anticardiolipin antibodies (ACA) of the G and M
classes. PAS sera and some selected paired CSF and serum specimens, were
also analyzed for the presence of anti-phosphatidylserine (PS) and
anti-phosphatidylethanolamine (PE) antibodies. High levels of IgG and
IgM ACA were synthesized intrathecally only in patients with
neurosyphilis. Patients with other infectious or inflammatory
neurological diseases very rarely showed detectable levels of ACA in
serum and/or CSF. ACA were found not only in patients with untreated PAS
but also in the serum of 3/7 patients with migraine, thus confirming a
relationship between ACA and vascular disorders. The search for PS and
PE antibodies disclosed that in PAS patients the serum titers of these
antibodies mirrored ACA IgG and IgM titers, while they were never found
in the CSF.
DE Adolescence Adult Antibodies,
Anticardiolipin/ANALYSIS/BLOOD/CEREBROSPINAL FLUID Antibodies,
Antiphospholipid/*ANALYSIS/BLOOD/CEREBROSPINAL FLUID Cerebral
Ischemia/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY Cerebrovascular
Disorders/BLOOD/CEREBROSPINAL FLUID/*IMMUNOLOGY Enzyme-Linked
Immunosorbent Assay Female Human HIV Infections/BLOOD/CEREBROSPINAL
FLUID/IMMUNOLOGY HIV-1 IgG/BIOSYNTHESIS/CEREBROSPINAL FLUID
IgM/BIOSYNTHESIS/CEREBROSPINAL FLUID Lipid Metabolism, Inborn
Errors/BLOOD/CEREBROSPINAL FLUID/ METABOLISM Male Middle Age
Migraine/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY Nervous System
Diseases/BLOOD/CEREBROSPINAL FLUID/*IMMUNOLOGY
Neurosyphilis/BLOOD/CEREBROSPINAL FLUID/IMMUNOLOGY
Phosphatidylethanolamines/IMMUNOLOGY/METABOLISM
Phosphatidylserines/IMMUNOLOGY/METABOLISM Support, Non-U.S. Gov't
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).